CyTOF makes it easy to observe the interaction between nanoparticles and immune cells. When nanoparticles interact with immune cells, they enter the cells to varying degrees depending on the nanoparticle's properties. Furthermore, immune cells react differently to nanoparticles depending on whether they participate in adaptive or innate immunity, and whether they are antigen-presenting cells or not. With CyTOF, it is feasible to simultaneously monitor how nanoparticles affect a number of immune cells


Effects of gold nanoparticles with protein corona on immune cell heterogeneity and cellular differentiation : A single cell based, high-dimensional mass cytometry study

Park et al. (2022) Submitted

#MassCytometry #Nanotoxicity #PBMC #ImmuneResponse #GoldNanoparticles

Mass Cytometry Exploration of Immunomodulatory Responses of Human Immune Cells Exposed to Silver Nanoparticles

Bae et al. (2022) Pharmaceutics, 14(3), 630;

#MassCytometry #Nanotoxicity #PBMC #ImmuneResponse #SilverNanoparticles

Mass Cytometry and Single‐Cell RNA‐seq Profiling of the Heterogeneity in Human Peripheral Blood Mononuclear Cells Interacting with Silver Nanoparticles

Ha et al. (2020) Small, 16 (21), 1907674;

#MassCytometry #scRNAseq #Nanotoxicity #PBMC #ImmuneResponse #SilverNanoparticles